Endocrine Abstracts

Background: There are only few reports regarding the role of serum galectin-3 (Gal-3) as an early biochemical marker in thyroid carcinoma.Aim: To evaluate the potential overexpression of Gal-3 in sera from patients with confirmed diagnosis of papillary thyroid carcinoma (PTC).Patients and methods: We retrospectively investigated serum Gal-3 in 40 patients referred to the surgical department for thyroidectomy. Sera were collected be...

Foreign bodies represent a rare cause of granulomatous mastitis. In the last three years we diagnosed three women with granulomatous mastitis consecutive to exposure at building materials containing glass fibers. All of them were young (21–34 years), with regular menses, without any pathological histories and were admitted to our hospital for bilateral galactorrhea spontaneous in one case and by squeezing the nipple in the other two cases. Clinical and ultrasonographic ev...

AbstractThyroid angiosarcoma is an aggressive and very rare type of thyroid malignancy originally diagnosed in iodine-deficient areas. The prognosis is poor and in most cases surgery proved to be inefficient. The fine needle aspiration biopsy (FNAB) and histology can rarely differentiate angiosarcoma from anaplastic carcinoma, and the final diagnosis is based on immunopositivity for vascular markers and absence of epithelial markers. We present he...

Introduction: Even the differentiated thyroid neoplasm have good prognostic, there are some particular cases that become very aggressive in short time, with poor management.Aim: We report a female case diagnosed with invasive papillary thyroid carcinoma.Case report: Seventy-three-year old female was diagnosed at age of 71 with a right lobe thyroid nodule (of almost 6 cm). At that moment the computed tomography (CT) of the cervical ...

Background: Angiogenesis are correlated with the aggressiveness, evolution’s rapidity and appearance of the locally advanced and metastatic medullary thyroid cancer (CMT), but in the same time is a selection criteria for actual therapy tested in the clinical studies.Objective: Study of angiogenesis in patients diagnosticated with CMT.Methods: Our study is conducted for 20 patients with sporadic and familial CMT, who are diagno...

Introduction: The current revised medullary thyroid carcinoma (MTC) guidelines don’t specify reference ranges of basal (bCT) or stimulated serum calcitonin (sCT) levels for the diagnosis of MTC. These are important for early diagnosis and correct management.Objective: We aimed to set gender specific thresholds for bCT and sCT for MTC diagnosis.Patients and methods: CT samples during calcium-stimulation test (2...

Introduction: Parathyroid carcinoma represents a very rare cause of primary hyperparathyroidism. It can be sporadic (most of cases), but also can occur in association with certain syndromes (multiple endocrine neoplasia, hyperparathyroidism-jaw tumor syndrome or isolated familial hyperparathyroidism).Case report: An 18-year-old woman was referred to the endocrine clinic because of a severe hypercalcemia, detected in the orthopedic surgery department, whe...

The coexistence of Graves disease (GD) and thyroid carcinoma used to be considered uncommon, but association between the two is being progressively acknowledged. Case report: We present the case of a 69-year-old woman with a 10 year history of GD who was referred to our clinic for fatigue, sweating, palpable cervical mass and weight loss. She was treated only in the previous 5 months with block and replace therapy. Laboratory workup at admission showed s...

Introduction: Matrix metalloproteinase-9 (MMP-9) is a zinc dependent proteolytic enzyme used by cells for degradation of the extracellular matrix during invasion and migration. There are only a few reports regarding the role played by MMP-9 in papillary thyroid carcinoma (PTC).Aim: To evaluate the association between MMP-9 secretion, reflected by preoperative serum levels and the histopathological features of thyroid tumors.Materia...

Introduction: The management of a thyroid nodule in a patient who is newly diagnosed with an active cancer depends not only of the thyroid disease its self but also of the prognosis of the second neoplasia.Aim: We present a case of a male who was admitted to an endocrinologist for a thyroid nodule evaluation.Case presentation: B.C., 66-year-old male patient, smoker from the last 17 years, was treated with thyamazol for hyperthyroid...